Lu et al. report that the association of different repeat types with distinct gene classes goes far beyond what has previously been shown and suggest that such relationship might be essential for gene function and regulation. As an example, they describe how long interspersed nuclear repeat (LINE1) transcripts are recruited together with associated genes to silent nuclear regions.
Keywords: LADs/NADs; LINE1; gene function; gene regulation; repetitive elements; transposons.
Published by Elsevier Ltd.