Abstract
Bacillus Calmette–Guérin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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BCG Vaccine / immunology
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BCG Vaccine / therapeutic use*
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Betacoronavirus
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COVID-19
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Coronavirus Infections / immunology
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Coronavirus Infections / prevention & control*
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Humans
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Immunity, Innate
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Immunogenicity, Vaccine
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Pandemics / prevention & control*
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Pneumonia, Viral / immunology
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Pneumonia, Viral / prevention & control*
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SARS-CoV-2