A new genetic variant of dengue serotype 2 virus circulating in the Peruvian Amazon

Francesca Falconi-Agapito; Philippe Selhorst; Xiomara Merino; Fiorella Torres; Johan Michiels; Connie Fernandez; Michael Talledo; Kevin K Ariën

doi:10.1016/j.ijid.2020.04.087

A new genetic variant of dengue serotype 2 virus circulating in the Peruvian Amazon

Int J Infect Dis. 2020 Jul:96:136-138. doi: 10.1016/j.ijid.2020.04.087. Epub 2020 May 6.

Authors

Francesca Falconi-Agapito¹, Philippe Selhorst², Xiomara Merino³, Fiorella Torres⁴, Johan Michiels⁵, Connie Fernandez⁶, Michael Talledo⁷, Kevin K Ariën⁸

Affiliations

¹ Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Nationalestraat 155, B-2000, Antwerp, Belgium; Unidad de Virología, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, 15102, Lima, Peru. Electronic address: francesca.falconi@upch.pe.
² Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Nationalestraat 155, B-2000, Antwerp, Belgium. Electronic address: pselhorst@itg.be.
³ Unidad de Virología, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, 15102, Lima, Peru. Electronic address: xiomara.merino@upch.pe.
⁴ Hospital Santa Gema, Yurimaguas, Calle Progreso 405, Yurimaguas, Alto Amazonas, 16501, Loreto, Peru. Electronic address: fiori.tote@gmail.com.
⁵ Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Nationalestraat 155, B-2000, Antwerp, Belgium. Electronic address: jmichiels@itg.be.
⁶ Hospital Santa Gema, Yurimaguas, Calle Progreso 405, Yurimaguas, Alto Amazonas, 16501, Loreto, Peru. Electronic address: connieaqp@yahoo.com.
⁷ Unidad de Virología, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, 15102, Lima, Peru. Electronic address: michael.talledo.a@upch.pe.
⁸ Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Nationalestraat 155, B-2000, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. Electronic address: karien@itg.be.

PMID: 32387448
DOI: 10.1016/j.ijid.2020.04.087

Abstract

We sequenced the envelope gene of dengue virus serotype 2 (DENV-2-E) in samples from an outbreak reported in 2018, in Yurimaguas, Peru. The strain belongs to lineage 2 of the American/Asian genotype. We report a variant with two novel mutations (I379T and V484I) located in domain III of DENV2-E.

Keywords: Dengue virus; Domain III; Envelope protein; Genotype; Lineage.

MeSH terms

Dengue / epidemiology
Dengue / virology*
Dengue Virus / classification
Dengue Virus / genetics*
Disease Outbreaks
Genetic Variation
Genotype
Humans
Peru / epidemiology
Phylogeny
Serogroup
Viral Envelope Proteins / genetics

Substances

E-glycoprotein, Dengue virus type 2
Viral Envelope Proteins