Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice

Mitsuru Tanaka; Hayato Kiyohara; Atsuko Yoshino; Akihiro Nakano; Fuyuko Takata; Shinya Dohgu; Yasufumi Kataoka; Toshiro Matsui

doi:10.1038/s41538-020-0067-3

Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide_25-35-induced memory impairment in mice

NPJ Sci Food. 2020 May 1:4:7. doi: 10.1038/s41538-020-0067-3. eCollection 2020.

Authors

Mitsuru Tanaka¹, Hayato Kiyohara¹, Atsuko Yoshino¹, Akihiro Nakano¹, Fuyuko Takata², Shinya Dohgu², Yasufumi Kataoka², Toshiro Matsui¹

Affiliations

¹ 1Laboratory of Food Analysis, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395 Japan.
² 2Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180 Japan.

Abstract

In this study, experiments on amyloid β peptide_25-35-induced mice were performed to provide in vivo evidence on the potential of the blood-brain barrier transportable soy dipeptide, Tyr-Pro, in combating memory impairment. We demonstrated for the first time that oral administration of Tyr-Pro (100 mg/kg, twice a day) in mice for 16 days significantly improved impaired memory by spontaneous alternation and shortened step-through latency in amyloid β-induced mice.

Keywords: Nutrition; Peptides.