Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields

Marco Stein; Hildegard Dohmen; Bernhard Wölk; Fabian Eberle; Malgorzata Kolodziej; Till Acker; Eberhard Uhl; Alexandra Jensen

doi:10.3389/fonc.2020.00477

Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields

Front Oncol. 2020 Apr 21:10:477. doi: 10.3389/fonc.2020.00477. eCollection 2020.

Authors

Marco Stein¹, Hildegard Dohmen², Bernhard Wölk³, Fabian Eberle^{4

5}, Malgorzata Kolodziej¹, Till Acker², Eberhard Uhl¹, Alexandra Jensen⁶

Affiliations

¹ Department of Neurosurgery, Justus-Liebig University, Giessen, Germany.
² Institute of Neuropathology, Justus-Liebig University, Giessen, Germany.
³ Department of Neuroradiology, Justus-Liebig University, Giessen, Germany.
⁴ Department of Radiotherapy and Radiooncology, UKGM Marburg, Marburg, Germany.
⁵ Marburg Particle Therapy Center (MIT), Marburg, Germany.
⁶ Department of Radiation Oncology, UKGM Giessen, Giessen, Germany.

Abstract

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. We present a case of a 42-year-old male patient presenting with headache and vomiting. Imaging demonstrated obstructive hydrocephalus and a ring-enhancing lesion in the right posterior thalamus. After endoscopic third ventriculostomy and stereotactic biopsy, the histopathologic diagnosis of a malignant glioma was confirmed by DNA methylation array as GBM isocitrate dehydrogenase wild type. The patient was treated with combined treatment of chemoradiation with temozolomide (TMZ) including proton boost, TMZ maintenance, and tumor-treating fields. In this case report, complete radiological response was observed 1 year after the end of radiation therapy.

Keywords: TTFields; biopsy; glioblastoma; proton therapy; radiological response.

Publication types

Case Reports