Gold nanorod-assisted near-infrared light-mediated regulation of membrane ion channels activates apoptotic pathways

Chem Commun (Camb). 2020 Jun 7;56(45):6118-6121. doi: 10.1039/d0cc01858a. Epub 2020 May 4.

Abstract

We report a GNR-assisted NIR-activated tool that could open TRPV1 ion channels and regulate apoptotic protein expression, thereby inducing cell apoptosis, which might be an effective approach for cancer therapy.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal / chemistry
  • Apoptosis / drug effects
  • CHO Cells
  • Cricetulus
  • Gold / administration & dosage*
  • Gold / chemistry
  • HEK293 Cells
  • Humans
  • Infrared Rays
  • Ion Channels
  • MCF-7 Cells
  • Nanotubes* / chemistry
  • TRPV Cation Channels / physiology*

Substances

  • Antibodies, Monoclonal
  • Ion Channels
  • TRPV Cation Channels
  • Gold