5-Hydroxymethylfurfural Synthesis from Monosaccharides by a Biphasic Reaction-Extraction System Using a Microreactor and Extractor

Yosuke Muranaka; Kenta Matsubara; Taisuke Maki; Shusaku Asano; Hiroyuki Nakagawa; Kazuhiro Mae

doi:10.1021/acsomega.0c00399

5-Hydroxymethylfurfural Synthesis from Monosaccharides by a Biphasic Reaction-Extraction System Using a Microreactor and Extractor

ACS Omega. 2020 Apr 15;5(16):9384-9390. doi: 10.1021/acsomega.0c00399. eCollection 2020 Apr 28.

Authors

Yosuke Muranaka¹, Kenta Matsubara¹, Taisuke Maki¹, Shusaku Asano², Hiroyuki Nakagawa¹, Kazuhiro Mae¹

Affiliations

¹ Department of Chemical Engineering, Kyoto University, Kyoto 615-8510, Japan.
² Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka 816-8580, Japan.

Abstract

5-Hydroxymethylfurfural (HMF) was synthesized from monosaccharides by a biphasic reaction system using a microreactor. The biphasic reaction system realized an immediate extraction and stabilization of product HMF, which further degrades under the reaction conditions. Segmented flow was utilized for an efficient reaction-extraction tool. The effect of extraction ability was evaluated based on the extraction phase/reaction phase partition coefficient of HMF. A Lewis acid catalyst was introduced to overcome the obstacle of the reaction, which was clarified as the isomerization of glucose to fructose, and improved the HMF yield to 85 mol % under the condition of T = 180 °C and τ = 47 min. The recovery of the product HMF was also examined using a constructed microextraction system, and HMF was selectively recovered from the extraction phase.