Recommended prophylactic and management strategies for severe acute respiratory syndrome coronavirus 2 infection in transplant recipients

Chun-Rong Ju; Qiao-Yan Lian; Jian-Heng Zhang; Tao Qiu; Zhi-Tao Cai; Wen-Yang Jiang; Jing Zhang; Qin Cheng; Gang Chen; Ning Li; Chun-Yan Wang; Jian-Xing He

doi:10.1016/j.cdtm.2020.02.003

Recommended prophylactic and management strategies for severe acute respiratory syndrome coronavirus 2 infection in transplant recipients

Chronic Dis Transl Med. 2020 Mar 27;6(2):87-97. doi: 10.1016/j.cdtm.2020.02.003. eCollection 2020 Jun.

Authors

Chun-Rong Ju¹, Qiao-Yan Lian¹, Jian-Heng Zhang¹, Tao Qiu², Zhi-Tao Cai², Wen-Yang Jiang³, Jing Zhang⁴, Qin Cheng⁵, Gang Chen⁶, Ning Li⁷, Chun-Yan Wang⁸, Jian-Xing He¹

Affiliations

¹ State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
² Department of Kidney Transplantation, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
³ Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
⁴ Department of Cardiovascular Surgery, Affiliated Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
⁵ Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100083, China.
⁶ Department of Kidney Transplantation, Affiliated Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430071, China.
⁷ Department of Kidney Transplantation, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.
⁸ Department of Hematology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.

Abstract

Since December 2019, increasing attention has been paid to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Wuhan, China. SARS-CoV-2 primarily invades the respiratory tract and lungs, leading to pneumonia and other systemic disorders. The effect of SARS-CoV-2 in transplant recipients has raised significant concerns, especially because there is a large population of transplant recipients in China. Based on the current epidemic situation, this study reviewed publications on this virus and coronavirus disease 2019 (COVID-19), analyzed common features of respiratory viral pneumonias, and presented the currently reported clinical characteristics of COVID-19 in transplant recipients to improve strategies regarding the diagnosis and treatment of COVID-19 in this special population.

Keywords: Corona virus disease 2019; Novel coronavirus; Pneumonia; Recipients; Transplantation.

Publication types

Review