Parenchymal pressure injury Ca2+ entry mechanism in pancreatitis

Robert Sutton

doi:10.1016/j.ceca.2020.102208

Parenchymal pressure injury Ca²⁺ entry mechanism in pancreatitis

Cell Calcium. 2020 Apr 19:88:102208. doi: 10.1016/j.ceca.2020.102208. Online ahead of print.

Author

Robert Sutton¹

Affiliation

¹ Liverpool Pancreatitis Research Group, Institute of Translational Medicine, University of Liverpool and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK. Electronic address: r.sutton@liverpool.ac.uk.

PMID: 32361508
DOI: 10.1016/j.ceca.2020.102208

Abstract

Pancreatic trauma and high parenchymal pressure have been found to open Piezo1 plasma membrane Ca²⁺ channels to such an extent that transient receptor potential vanilloid type 4 channels also open to further Ca²⁺ entry, overloading the cell with Ca²⁺ to induce acute pancreatitis (Swain et al, J Clin Invest, 2020). Elucidation of this mechanism is an important step in understanding pancreatitis and opens up new possibilities for prevention and treatment.

Keywords: Ca(2+)overload; Orai1; Piezo1; TRPV4; drug target; pancreatitis.

Grants and funding

15/20/01/DH_/Department of Health/United Kingdom