Current knowledge on Hepatitis Delta Virus replication

Julie Lucifora; Marion Delphin

doi:10.1016/j.antiviral.2020.104812

Current knowledge on Hepatitis Delta Virus replication

Antiviral Res. 2020 Jul:179:104812. doi: 10.1016/j.antiviral.2020.104812. Epub 2020 Apr 29.

Authors

Julie Lucifora¹, Marion Delphin²

Affiliations

¹ INSERM, U1052, Cancer Research Center of Lyon (CRCL), Université de Lyon (UCBL1), CNRS UMR_5286, France. Electronic address: julie.lucifora@inserm.fr.
² INSERM, U1052, Cancer Research Center of Lyon (CRCL), Université de Lyon (UCBL1), CNRS UMR_5286, France.

PMID: 32360949
DOI: 10.1016/j.antiviral.2020.104812

Abstract

Hepatitis B Virus (HBV) that infects liver parenchymal cells is responsible for severe liver diseases and co-infection with Hepatitis Delta Virus (HDV) leads to the most aggressive form of viral hepatitis. Even tough being different for their viral genome (relaxed circular partially double stranded DNA for HBV and circular RNA for HDV), HBV and HDV are both maintained as episomes in the nucleus of infected cells and use the cellular machinery for the transcription of their viral RNAs. We propose here an update on the current knowledge on HDV replication cycle that may eventually help to identify new antiviral targets.

Keywords: Episome; Hepatitis B virus (HBV); Hepatitis delta virus (HDV); Hepatocyte; Life cycle.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Nucleus / virology*
Coinfection / virology
Genome, Viral
Hepatitis B virus / physiology
Hepatitis Delta Virus / genetics*
Hepatitis Delta Virus / physiology*
Hepatitis, Viral, Human
Hepatocytes / virology*
Humans
Mice
Plasmids
Virus Replication*