The gut microbiome in psoriasis and psoriatic arthritis

Bridget Myers; Nicholas Brownstone; Vidhatha Reddy; Stephanie Chan; Quinn Thibodeaux; Alexa Truong; Tina Bhutani; Hsin-Wen Chang; Wilson Liao

doi:10.1016/j.berh.2020.101494

The gut microbiome in psoriasis and psoriatic arthritis

Best Pract Res Clin Rheumatol. 2019 Dec;33(6):101494. doi: 10.1016/j.berh.2020.101494. Epub 2020 Apr 29.

Authors

Bridget Myers¹, Nicholas Brownstone², Vidhatha Reddy³, Stephanie Chan⁴, Quinn Thibodeaux⁵, Alexa Truong⁶, Tina Bhutani⁷, Hsin-Wen Chang⁸, Wilson Liao⁹

Affiliations

¹ University of California San Francisco Department of Dermatology, San Francisco, CA, USA. Electronic address: Bridget.myers@ucsf.edu.
² University of California San Francisco Department of Dermatology, San Francisco, CA, USA. Electronic address: Nicholas.brownstone@ucsf.edu.
³ University of California San Francisco Department of Dermatology, San Francisco, CA, USA. Electronic address: Vidhatha.reddy@ucsf.edu.
⁴ University of California San Francisco Department of Dermatology, San Francisco, CA, USA. Electronic address: Stephanie.chan@ucsf.edu.
⁵ University of California San Francisco Department of Dermatology, San Francisco, CA, USA. Electronic address: Quinn.thibodeaux@ucsf.edu.
⁶ University of California Berkeley, Berkeley, CA, USA. Electronic address: Alexatruong13@berkeley.edu.
⁷ University of California San Francisco Department of Dermatology, San Francisco, CA, USA. Electronic address: Tina.bhutani@ucsf.edu.
⁸ University of California San Francisco Department of Dermatology, San Francisco, CA, USA. Electronic address: HsinWen.Chang@ucsf.edu.
⁹ University of California San Francisco Department of Dermatology, San Francisco, CA, USA. Electronic address: wilson.liao@ucsf.edu.

PMID: 32360228
DOI: 10.1016/j.berh.2020.101494

Abstract

This review summarizes existing research on the gut microbiome composition and function in psoriasis and psoriatic arthritis, exploring potential roles in disease pathogenesis, progression, and management. A strong relationship between skin, joint, and gastrointestinal inflammation exists, as demonstrated by an increased prevalence of psoriasis, psoriatic arthritis, and inflammatory bowel disease co-occurring together; however, the link between them has not been fully elucidated. Studies analyzing the gut microbiome in psoriasis and psoriatic arthritis reveal a unique pattern of dysbiosis. With regard to the gut microbiome's role in psoriasis and psoriatic arthritis pathogenesis, we discuss several theories including intestinal permeability, altered immune homeostasis, and imbalance of short- and medium-chain fatty acid-producing bacteria. We also discuss how the gut microbiome affects patient risk of psoriatic arthritis and other serious comorbidities, and how fecal microbes could be used clinically as therapeutic targets or markers of disease.

Keywords: Dysbiosis; Metagenome; Microbiome; Microbiota; Psoriasis; Psoriatic arthritis.

Publication types

Review

MeSH terms

Arthritis, Psoriatic* / microbiology
Dysbiosis
Gastrointestinal Microbiome*
Humans
Microbiota*
Psoriasis*