Serum uric acid concentration is not associated with handgrip strength, lean body mass or survival in gastrointestinal cancer patients

Abstract

Background and aims: Serum uric acid (UA) concentrations are associated with physical capacity and muscle strength. In cancer patients, this relationship may influence the prognosis and survival. However, studies are controversial and require further research. Thus, this study aimed to evaluate if there is an association between the serum UA concentrations with handgrip strength (HGS), lean body mass (LBM) and survival probability in gastrointestinal tract cancer patients.

Methods: A retrospective cross-sectional study enrolled patients of both genders and over 18 years old. All data was collected from medical records after an initial consultation with a dietitian. UA concentrations were dichotomized using the sample mean values, high ≥4.17 mg/dL and low <4.17 mg/dL.

Results: From the 101 patients, 46 were women and 55 men. Those with high UA also included individuals with a history of smoking (p = 0.004), greater HGS (p = 0.008), greater LBM (p = 0.026) and a greater total caloric intake (p = 0.028). In the logistic regression analysis, no association was found between UA and HGS (OR: 1.03 95% CI: 0.96-1.10, p = 0.337) and LBM (OR: 1.03 95% CI: 0.96-1.11, p = 0.301) after adjusting for gender, whether or not the patient smokes, and total caloric intake. Further, survival probability did not change among the high and low UA concentrations.

Conclusion: In gastrointestinal tract cancer patients, serum UA concentrations were not linked to muscle strength, lean mass nor survival.

Keywords: Cancer; Handgrip strength; Lean body mass; Survival probability; Uric acid.