High-level induction of fetal haemoglobin by pomalidomide in β-thalassaemia/HbE erythroid progenitor cells

Br J Haematol. 2020 Jun;189(6):e240-e245. doi: 10.1111/bjh.16670. Epub 2020 May 2.

Authors

Affiliations

¹ Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.
² Department of Forensic Science, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani, Thailand.
³ Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
⁴ Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
⁵ Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
⁶ Department of Medical Sciences, National Institute of Health, Ministry of Public Health, Nonthaburi, Thailand.

PMID: 32358840
DOI: 10.1111/bjh.16670

No abstract available

Keywords: decitabine; fetal haemoglobin induction; hydroxyurea; pomalidomide; β-thalassaemia/HbE.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Erythroid Precursor Cells / metabolism*
Erythroid Precursor Cells / pathology
Fetal Hemoglobin / biosynthesis*
Gene Expression Regulation / drug effects*
Hemoglobin E / biosynthesis*
Humans
Thalidomide / analogs & derivatives*
Thalidomide / pharmacology
beta-Thalassemia / drug therapy
beta-Thalassemia / metabolism*
beta-Thalassemia / pathology

Substances

Thalidomide
Hemoglobin E
Fetal Hemoglobin
pomalidomide

Grants and funding