Abstract
Herein, we report an eco-friendly, electrosynthetic approach for the intramolecular oxyselenylation of allyl-naphthol/phenol derivatives. This reaction proceeds with 0.2 equiv. of nBu4NClO4 as an electrolyte and Pt working electrodes in an undivided cell, resulting in the selenyl-dihydrofurans in good to excellent yields. Furthermore, several of the synthesized products presented a high percentage of acetylcholinesterase (AChE) inhibition, highlighting their potential anti-Alzheimer activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / metabolism
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Cholinesterase Inhibitors / chemical synthesis
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / pharmacology*
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Dose-Response Relationship, Drug
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Electrochemical Techniques*
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Electrodes
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Furans / chemical synthesis
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Furans / chemistry
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Furans / pharmacology*
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Humans
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Molecular Structure
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Naphthols / chemistry
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Naphthols / pharmacology*
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Organoselenium Compounds / chemical synthesis
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Organoselenium Compounds / chemistry
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Organoselenium Compounds / pharmacology*
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Phenols / chemistry
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Phenols / pharmacology*
Substances
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Cholinesterase Inhibitors
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Furans
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Naphthols
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Organoselenium Compounds
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Phenols
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Acetylcholinesterase