Initial combination therapy of macitentan and tadalafil in pulmonary arterial hypertension

Olivier Sitbon; Vincent Cottin; Matthieu Canuet; Pierre Clerson; Virginie Gressin; Loïc Perchenet; Laurent Bertoletti; Hélène Bouvaist; François Picard; Grégoire Prévot; Emmanuel Bergot; Gérald Simonneau

doi:10.1183/13993003.00673-2020

Initial combination therapy of macitentan and tadalafil in pulmonary arterial hypertension

Eur Respir J. 2020 Sep 3;56(3):2000673. doi: 10.1183/13993003.00673-2020. Print 2020 Sep.

Authors

Affiliations

¹ APHP, National Reference Centre for Pulmonary Hypertension, Dept of Respiratory and Intensive Care Medicine, Bicêtre Hospital, University Paris-Sud - University Paris Saclay, INSERM UMR_S999, Le Kremlin-Bicêtre, France olivier.sitbon@u-psud.fr.
² National Reference Centre for Rare Pulmonary Diseases, Dept of Pneumology, Louis Pradel Hospital, Claude Bernard University Lyon 1, UMR754, Lyon, France.
³ Dept of Pneumology, Nouvel Hôpital Civil, Strasbourg, France.
⁴ Soladis Clinical Studies, Biostatistics, Roubaix, France.
⁵ Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.
⁶ Dept of Vascular Medicine and Therapeutics, Saint-Étienne University Hospital Centre, Saint-Étienne, France.
⁷ INSERM (National Institute of Health and Medical Research) U1059 and INSERM CIC1408, Saint-Étienne, France.
⁸ Cardiology Service, Michallon Hospital, Grenoble University Hospital Centre, Grenoble, France.
⁹ Heart Failure Unit and Pulmonary Hypertension Expert Centre, Bordeaux University Hospital, Bordeaux, France.
¹⁰ Dept of Pneumology, University Hospital, Toulouse, France.
¹¹ Dept of Pneumology, University Hospital, Caen, France.
¹² APHP, National Reference Centre for Pulmonary Hypertension, Dept of Respiratory and Intensive Care Medicine, Bicêtre Hospital, University Paris-Sud - University Paris Saclay, INSERM UMR_S999, Le Kremlin-Bicêtre, France.

Abstract

Initial combination therapy with macitentan and tadalafil is well tolerated and improves cardiopulmonary haemodynamics and functional capacity in newly diagnosed PAH patients https://bit.ly/3aWZagH

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Drug Therapy, Combination
Endothelin Receptor Antagonists
Humans
Pulmonary Arterial Hypertension*
Pyrimidines
Sulfonamides
Tadalafil

Substances

Endothelin Receptor Antagonists
Pyrimidines
Sulfonamides
Tadalafil
macitentan