Human serum albumin-mediated recognition of soluble amyloid-β peptides using a time-resolved luminescent probe in plasma

Chengyi Yuan; Weiping Duan; Jian Luo; Yuwang Han; Xiaohui Wang

doi:10.1039/d0cc01384f

Human serum albumin-mediated recognition of soluble amyloid-β peptides using a time-resolved luminescent probe in plasma

Chem Commun (Camb). 2020 Jun 4;56(44):5945-5948. doi: 10.1039/d0cc01384f. Epub 2020 Apr 29.

Authors

Chengyi Yuan¹, Weiping Duan, Jian Luo, Yuwang Han, Xiaohui Wang

Affiliation

¹ College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China. wangxhui@njtech.edu.cn.

PMID: 32347243
DOI: 10.1039/d0cc01384f

Abstract

A terbium(iii) complex can recognize soluble Aβ in plasma through human serum albumin (HSA)-mediated co-assembly, which can not only circumvent the interference of HSA, but also benefit Aβ enrichment with amplified time-resolved luminescence enhancement.

MeSH terms

Amyloid beta-Peptides / blood
Amyloid beta-Peptides / chemistry*
Fluorescent Dyes / chemistry*
Luminescence
Serum Albumin, Human / chemistry*
Terbium / chemistry*

Substances

Amyloid beta-Peptides
Fluorescent Dyes
Terbium
Serum Albumin, Human