Accentuation influences selective attention and the depth of semantic processing during online speech comprehension. We investigated the processing of semantically congruent and incongruent words in a language that presents cues to prosodic prominences in the region of the utterance occurring after the focussed information (the post-focal region). This language is Italian, in particular the variety spoken in Bari. In this variety, questions have a compressed, post-focal accent, whereas in statements there is a low-level pitch in this position. Using event-related potentials, we investigated the processing of congruent and incongruent target words with two prosodic realizations (focussed with accentuation, post-focal realization) and in two-sentence modalities (statement, question). Results indicate an N400 congruence effect that was modulated by position (focal, post-focal) and modality (statement, question): processing was deeper for questions in narrow focus than in post-focal position, while statements showed similar pronounced N400 effects across positions. The attenuated N400 difference for post-focal targets in questions was accompanied by a more enhanced late positivity when they were incongruent, indicating that attentional resources are allocated during updating of speech act information.