Evidence of Failure of Oral Third-Generation Cephalosporin Treatment for Shigella sonnei Infection

Jennifer P Collins; Cindy R Friedman; Meseret G Birhane; Beth E Karp; Anthony Osinski; Mary W Montgomery; Deepam Thomas; Jonathan Barkley; Martha C Sanchez; Samir Hanna; Azizat A Adediran; Jessica C Chen; Hayat Caidi; Louise Francois Watkins

doi:10.1093/ofid/ofaa113

Evidence of Failure of Oral Third-Generation Cephalosporin Treatment for Shigella sonnei Infection

Open Forum Infect Dis. 2020 Apr 18;7(4):ofaa113. doi: 10.1093/ofid/ofaa113. eCollection 2020 Apr.

Authors

Affiliations

¹ Epidemic Intelligence Service, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Enteric Diseases Epidemiology Branch, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
³ Massachusetts Department of Public Health, Bureau of Infectious Disease and Laboratory Sciences, Boston, Massachusetts, USA.
⁴ Brigham and Women's Hospital, Division of Infectious Diseases, Boston, Massachusetts, USA.
⁵ New Jersey Department of Health, Communicable Disease Service, Trenton, New Jersey, USA.
⁶ Rhode Island Department of Health, Center for Acute Infectious Disease Epidemiology, Providence, Rhode Island, USA.
⁷ Brown Medicine, Division of Infectious Diseases, Providence, Rhode Island, USA.
⁸ Tennessee Department of Health, Communicable and Environmental Diseases and Emergency Preparedness, Nashville, Tennessee, USA.
⁹ Enteric Diseases Laboratory Branch, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Abstract

In 2017, state health departments notified the Centers for Disease Control and Prevention about 4 patients with shigellosis who experienced persistent illness after treatment with oral third-generation cephalosporins. Given increasing antibiotic resistance among Shigella, these cases highlight the need to evaluate the efficacy of oral cephalosporins for shigellosis.

Keywords: Shigella sonnei; antibiotic resistance; antibiotic treatment failure; cephalosporin; shigellosis.

Published by Oxford University Press on behalf of Infectious Diseases Society of America 2020.