Early Leukapheresis Depletion in an Ex-Premature with Severe Acute Respiratory Distress Syndrome Due to Bordetella Pertussis and Coronavirus Infection

Blood Purif. 2020;49(6):758-760. doi: 10.1159/000507873. Epub 2020 Apr 27.

Abstract

We describe a 2 weeks corrected gestational age infant admitted in pediatric intensive care unit (PICU) for severe acute respiratory distress syndrome (ARDS) associated to Bordetella pertussis and Coronavirus infection. He developed leukocytosis as soon as ARDS required intubation and aggressive mechanical ventilation: hence he underwent 3 early therapeutic leukapheresis treatments in order to avoid the worsening of related cardiopulmonary complications, according to recent literature on pertussis infection in infants. The infant was discharged from PICU healthy.

Keywords: Acute respiratory distress syndrome; Bordetella pertussis; Hyperleukocytosis; Infant; Intensive care; Leukapheresis; Pediatric; Pulmonary hypertension.

Publication types

  • Case Reports

MeSH terms

  • Bordetella pertussis / isolation & purification*
  • Coinfection / blood
  • Coinfection / complications*
  • Coinfection / microbiology
  • Coinfection / virology
  • Combined Modality Therapy
  • Continuous Positive Airway Pressure
  • Coronavirus / isolation & purification*
  • Coronavirus Infections / blood
  • Coronavirus Infections / complications*
  • Coronavirus Infections / virology
  • Humans
  • Infant
  • Leukapheresis*
  • Leukocytosis / etiology
  • Leukocytosis / therapy*
  • Male
  • Respiration, Artificial
  • Respiratory Distress Syndrome, Newborn / blood
  • Respiratory Distress Syndrome, Newborn / etiology*
  • Respiratory Distress Syndrome, Newborn / therapy
  • Whooping Cough / blood
  • Whooping Cough / complications*