Human Epididymis Protein 4 Levels in Neonates with Respiratory Disorder

Piotr Surmiak; Martyna Szymkowiak; Małgorzata Baumert

doi:10.1155/2020/1509379

Human Epididymis Protein 4 Levels in Neonates with Respiratory Disorder

Biomed Res Int. 2020 Apr 2:2020:1509379. doi: 10.1155/2020/1509379. eCollection 2020.

Authors

Piotr Surmiak¹, Martyna Szymkowiak¹, Małgorzata Baumert¹

Affiliation

¹ Department of Neonatology, Medical University of Silesia in Katowice, Faculty of Medical Sciences, Katowice 40-055, Poland.

Abstract

Results: There were no differences found in the HE4 levels determined for the mothers' blood samples and umbilical cord blood samples in all investigated groups. In comparison with healthy children, the elevated HE4 levels were observed in neonates with TTN. Significant positive correlation between HE4 and CRP as well as PCT levels was observed in all investigated neonates. The receiver operating characteristic (ROC) curve analysis demonstrated the cut-off value for the serum HE4 in the researched neonates at the level of 318.5 pmol/L, yielding the sensitivity of 73.9% and specificity of 66.7% for the early diagnosis of TTN.

Conclusions: Serum HE4 could be considered as a candidate biomarker for the early diagnosis of pulmonary dysfunction in the newborns.

MeSH terms

Adult
Biomarkers / blood
C-Reactive Protein / analysis
Female
Fetal Blood / chemistry
Humans
Infant, Newborn
Male
Prospective Studies
Sensitivity and Specificity
Transient Tachypnea of the Newborn / blood
Transient Tachypnea of the Newborn / diagnosis*
WAP Four-Disulfide Core Domain Protein 2 / analysis*

Substances

Biomarkers
WAP Four-Disulfide Core Domain Protein 2
WFDC2 protein, human
C-Reactive Protein