High concentration of glucose induces filaggrin-1 expression through AP-1 in skin keratinocytes

J Dermatol Sci. 2020 May;98(2):137-140. doi: 10.1016/j.jdermsci.2020.04.002. Epub 2020 Apr 14.

Authors

Masae Furukawa¹, Kiyoko Yamada², Mie Kurosawa¹, Yosuke Shikama¹, Jingshu Wang¹, Maki Watanabe¹, Takuro Kanekura³, Kenji Matsushita⁴

Affiliations

¹ Department of Oral Disease Research, National Center for Geriatrics and Gerontology, Obu, Japan.
² Department of Dermatology, Department of Longevity Oral Science, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
³ Department of Dermatology, Department of Longevity Oral Science, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Electronic address: takurok@m2.kufm.kagoshima-u.ac.jp.
⁴ Department of Oral Disease Research, National Center for Geriatrics and Gerontology, Obu, Japan. Electronic address: kmatsu30@ncgg.go.jp.

PMID: 32336501
DOI: 10.1016/j.jdermsci.2020.04.002

No abstract available

Publication types

Letter

MeSH terms

Administration, Cutaneous
Cells, Cultured
Colforsin / pharmacology
Culture Media / metabolism
Dermatitis, Atopic / drug therapy
Dermatitis, Atopic / pathology
Filaggrin Proteins
Glucose / administration & dosage
Glucose / metabolism*
Glucose Transporter Type 1 / antagonists & inhibitors
Glucose Transporter Type 1 / metabolism
Humans
Keratinocytes / metabolism
Primary Cell Culture
S100 Proteins / genetics*
Transcription Factor AP-1 / metabolism*
Up-Regulation / drug effects

Substances

Culture Media
FLG protein, human
Filaggrin Proteins
Glucose Transporter Type 1
S100 Proteins
SLC2A1 protein, human
Transcription Factor AP-1
Colforsin
Glucose