Bacterial outer membrane vesicles as a platform for biomedical applications: An update

Min Li; Han Zhou; Chen Yang; Yi Wu; Xuechang Zhou; Hang Liu; Yucai Wang

doi:10.1016/j.jconrel.2020.04.031

Bacterial outer membrane vesicles as a platform for biomedical applications: An update

J Control Release. 2020 Jul 10:323:253-268. doi: 10.1016/j.jconrel.2020.04.031. Epub 2020 Apr 22.

Authors

Min Li¹, Han Zhou², Chen Yang², Yi Wu², Xuechang Zhou³, Hang Liu⁴, Yucai Wang⁵

Affiliations

¹ College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China; Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
² Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
³ College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China.
⁴ Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: hangliu@ustc.edu.cn.
⁵ Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: yucaiwang@ustc.edu.cn.

PMID: 32333919
DOI: 10.1016/j.jconrel.2020.04.031

Abstract

Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria both in vitro and in vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer membranes and contain multiple parent bacteria-derived components. Based on the presence of bacterial antigens, pathogen-associated molecular patterns (PAMPs), adhesins, various proteins and the vesicle structure, OMVs have been developed for biomedical applications as bacterial vaccines, adjuvants, cancer immunotherapy agents, drug delivery vehicles, and anti-bacteria adhesion agents. In this review, we analyze the contributions of the structure and composition of OMVs to their applications, summarize the methods used to isolate and characterize OMVs, and highlight recent progress and future perspectives of OMVs in biomedical applications.

Keywords: Adjuvants; Anti-bacteria adhesion agents; Bacterial vaccines; Cancer immunotherapy agents; Drug delivery vehicles; Outer membrane vesicles.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bacterial Outer Membrane Proteins
Bacterial Outer Membrane*
Bacterial Vaccines
Extracellular Vesicles*
Gram-Negative Bacteria

Substances

Bacterial Outer Membrane Proteins
Bacterial Vaccines