Net Effects of NETs: New Concepts

Teruki Dainichi; Saeko Nakajima; Masashi Iwata; Kenji Kabashima

doi:10.1016/j.jid.2019.12.016

Net Effects of NETs: New Concepts

J Invest Dermatol. 2020 May;140(5):939-941. doi: 10.1016/j.jid.2019.12.016.

Authors

Teruki Dainichi¹, Saeko Nakajima², Masashi Iwata², Kenji Kabashima³

Affiliations

¹ Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: dainichi@kuhp.kyoto-u.ac.jp.
² Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
³ Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network and Skin Research Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.

PMID: 32331568
DOI: 10.1016/j.jid.2019.12.016

Abstract

It is challenging to investigate neutrophil extracellular traps (NETs) and bacterial colonization in vivo. Bitschar et al. (2020) oppose an existing paradigm regarding neutrophils in host defense and propose that neutrophils increase Staphylococcus aureus skin colonization through NETs, not by trapping microbes but via indirect mechanisms. These results are open to interpretation and should stimulate productive discussions.

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MeSH terms

Extracellular Traps*
Keratinocytes
Neutrophils
Skin
Staphylococcus aureus