Abstract
Herein, we present a series of dual-targeted ruthenium-glucose conjugates that can function as two-photon absorption (TPA) PDT agents to effectively destroy tumors by preferentially targeting both tumor cells and mitochondria. The in vivo experiments revealed an excellent tumor inhibitory efficiency of the dual-targeted TPA PSs.
MeSH terms
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Animals
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Cell Line
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Cell Survival / drug effects
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Glucose / pharmacology
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Glucose / therapeutic use*
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Humans
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Light
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Mice, Inbred BALB C
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Mitochondria / metabolism*
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Neoplasms / drug therapy*
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Neoplasms / metabolism
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Neoplasms / pathology
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Photochemotherapy*
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Photosensitizing Agents / pharmacology
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Photosensitizing Agents / therapeutic use*
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Ruthenium / pharmacology
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Ruthenium / therapeutic use*
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Tumor Burden / drug effects
Substances
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Photosensitizing Agents
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Ruthenium
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Glucose