Recently a COVID-19 pneumonia pandemic caused by a novel coronavirus 2019-nCoV has broken out over the world. In order to better control the spread of the pandemic, there's an urgent need to extensively study the virus' origin and the mechanisms for its infectivity and pathogenicity. Spike protein is a special structural protein on the surface of coronavirus. It contains important information about the evolution of the virus and plays critical roles in the processes of cellular recognition and entry. In the past decades, spike protein has always been one of the most important objects in research works on coronaviruses closely related to human life. In this review we introduce these research works related to spike proteins, hoping it will provide reasonable ideas for the control of the current pandemic, as well as for the diagnosis and treatment of COVID-19.
最近，一种由新型冠状病毒 2019-nCoV 引起的 COVID-19 肺炎疫情在全球暴发。为了更好地控制疫情的蔓延，亟需对 2019-nCoV 的来源、传播和致病机制进行深入研究。刺突（spike）蛋白是冠状病毒表面特有的结构蛋白，包含了冠状病毒自然演化的重要信息，并在病毒识别和入侵人体细胞的过程中起到关键作用。最近十几年，在对与人类密切相关的冠状病毒的研究中，spike 蛋白一直是最为重要的研究对象之一。而在 COVID-19 肺炎疫情暴发后，2019-nCoV 病毒表面的 spike 蛋白也迅速成为研究的焦点。本文旨在通过介绍 spike 蛋白相关研究，以期为当前疫情的防控以及 COVID-19 的诊断和治疗提供合理的研究思路。.
Keywords: antibody; coronavirus; spike protein; vaccine.