Abstract
The similarity is an important category in natural sciences. A measure of similarity for a group of various biochemical endpoints is suggested. The list of examined endpoints contains (1) toxicity of pesticides towards rainbow trout; (2) human skin sensitization; (3) mutagenicity; (4) toxicity of psychotropic drugs; and (5) anti HIV activity. Further applying and evolution of the suggested approach is discussed. In particular, the conception of the similarity (dissimilarity) of endpoints can play the role of a "useful bridge" between quantitative structure property/activity relationships (QSPRs/QSARs) and read-across technique.
Keywords:
Biochemical endpoints; Index of ideality of correlation; Monte Carlo method; QSAR; Similarity/dissimilarity of endpoints.
MeSH terms
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Amines / chemistry
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Amines / toxicity
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Animals
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Anti-Anxiety Agents / chemistry
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Anti-Anxiety Agents / toxicity
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Antidepressive Agents / chemistry
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Antidepressive Agents / toxicity
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Antipsychotic Agents / chemistry
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Antipsychotic Agents / toxicity
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Cosmetics / chemistry
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Cosmetics / toxicity
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HIV Protease Inhibitors / chemistry
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HIV Protease Inhibitors / pharmacology
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Haptens / chemistry
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Haptens / toxicity
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Humans
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Lethal Dose 50
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Local Lymph Node Assay
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Models, Molecular*
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Mutagens / chemistry
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Mutagens / toxicity
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Oncorhynchus mykiss
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Pesticides / chemistry
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Pesticides / toxicity
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Phenothiazines / chemistry
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Phenothiazines / toxicity
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Quantitative Structure-Activity Relationship
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Salmonella typhimurium / drug effects
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Salmonella typhimurium / genetics
Substances
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Amines
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Anti-Anxiety Agents
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Antidepressive Agents
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Antipsychotic Agents
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Cosmetics
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HIV Protease Inhibitors
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Haptens
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Mutagens
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Pesticides
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Phenothiazines