Carbapenemase-producing Klebsiella pneumoniae intra-abdominal infection successfully treated with ceftazidime/avibactam plus tigecycline

Mariana Guedes; Raquel Duro; Telma Fonseca; Isabel Abreu; Nuno Rocha-Pereira

doi:10.1016/j.idcr.2020.e00745

Carbapenemase-producing Klebsiella pneumoniae intra-abdominal infection successfully treated with ceftazidime/avibactam plus tigecycline

IDCases. 2020 Apr 4:20:e00745. doi: 10.1016/j.idcr.2020.e00745. eCollection 2020.

Authors

Mariana Guedes¹, Raquel Duro¹, Telma Fonseca², Isabel Abreu¹, Nuno Rocha-Pereira¹

Affiliations

¹ Infectious Diseases Department, Centro Hospitalar Universitário de São João Alameda Prof. Hernâni Monteiro, 4200-319, Oporto, Portugal.
² General Surgery Deparment, Centro Hospitalar Universitário de São João Alameda Prof. Hernâni Monteiro, 4200-319, Oporto, Portugal.

Abstract

Ceftazidime/avibactam combines ceftazidime with a new beta-lactam that successfully that inhibits Amber Class A and D carbapenemases. We report a clinical case of a 61 year-old man with a carbapenemase-producing Klebsiella pneumoniae intra-abdominal infection after an elective abdominal hernia repair. The infection was successfully managed with multiple abdominal surgeries, drainage and combined antibiotic therapy with ceftazidime/avibactam plus tigecycline.

Keywords: Carbapenemase-producing Klebsiella pneumoniae; Ceftazidime/avibactam; Intra-abdominal infection; Tigecycline.

Publication types

Case Reports