Exosomes as Sentinels against Bacterial Pathogens

Elena Panizza; Richard A Cerione; Marc A Antonyak

doi:10.1016/j.devcel.2020.03.022

Exosomes as Sentinels against Bacterial Pathogens

Dev Cell. 2020 Apr 20;53(2):138-139. doi: 10.1016/j.devcel.2020.03.022.

Authors

Elena Panizza¹, Richard A Cerione², Marc A Antonyak¹

Affiliations

¹ Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.
² Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. Electronic address: rac1@cornell.edu.

Abstract

The ability of cells to form and release multiple classes of extracellular vesicles (EVs) is an increasingly well-recognized phenomenon. EVs are best known as mediators of intercellular communication. However, in a recent issue of Nature, Keller et al. show that they function as decoys to mitigate bacterial toxins.

Publication types

Comment

MeSH terms

Bacteria
Bacterial Toxins*
Cell Communication
Exosomes*
Extracellular Vesicles*

Substances

Bacterial Toxins

Grants and funding

R35 GM122575/GM/NIGMS NIH HHS/United States