COVID-19 in a high-risk dual heart and kidney transplant recipient

Am J Transplant. 2020 Jul;20(7):1911-1915. doi: 10.1111/ajt.15936. Epub 2020 Jun 22.

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly infecting people worldwide, resulting in the infectious disease coronavirus disease 19 (COVID-19) that has been declared a pandemic. Much remains unknown about COVID-19, including its effects on solid organ transplant (SOT) recipients. Given their immunosuppressed state, SOT recipients are presumed to be at high risk of complications with viral infections such as SARS-CoV-2. Limited case reports in single SOT recipients, however, have not suggested a particularly severe course in this population. In this report, we present a dual-organ (heart/kidney) transplant recipient who was found to have COVID-19 and, despite the presence of a number of risk factors for poor outcomes, had a relatively mild clinical course.

Keywords: biomarker; clinical research/practice; diabetes: type 2; graft survival; heart transplantation/cardiology; immunosuppressive regimens - minimization/withdrawal; infection and infectious agents - viral; infectious disease; kidney transplantation/nephrology.

Publication types

  • Case Reports

MeSH terms

  • Adenosine Monophosphate / administration & dosage
  • Adenosine Monophosphate / analogs & derivatives
  • Adult
  • Alanine / administration & dosage
  • Alanine / analogs & derivatives
  • Betacoronavirus
  • COVID-19
  • Cardiomyopathy, Dilated / complications*
  • Cardiomyopathy, Dilated / surgery
  • Coronavirus Infections / complications
  • Coronavirus Infections / diagnosis*
  • Heart Transplantation*
  • Humans
  • Hydroxychloroquine / administration & dosage
  • Immunocompromised Host
  • Immunosuppression Therapy / adverse effects
  • Immunosuppressive Agents / adverse effects
  • Kidney Failure, Chronic / complications*
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation*
  • Male
  • Pandemics
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / diagnosis*
  • Radiography, Thoracic
  • Randomized Controlled Trials as Topic
  • Risk Factors
  • SARS-CoV-2
  • Treatment Outcome

Substances

  • Immunosuppressive Agents
  • remdesivir
  • Adenosine Monophosphate
  • Hydroxychloroquine
  • Alanine