Application of optical clearing of biological tissue in humans in vivo is challenging due to toxicity of chemical agents, long processing time (≥30 min), and moderate (1.3-1.5-fold) imaging depth improvement. Here, we introduce novel, robust, and rapid ultrasound-based optical clearing of human skin without chemical agents that provides dramatic (up to 10-fold) reducing processing time down to 2-5 min. We discovered that ultrasound alone can increase a light depth penetration for optical coherence tomography (OCT) up to ~1.5-fold during 2 min. Nevertheless, sequent application of microdermabrasion, oleic acid and ultrasound allowed increasing OCT signal amplitude up to 3.3-fold with more than twice improved depth penetration during 30 min that was not demonstrated with other approaches. Comparison of these effects in light and dark skin revealed similarity of the optical clearing mechanisms. However, for combined optical clearing, only 1.34-fold increase in OCT signal amplitude was achieved for dark skin.