Sleeping Patterns in Patients with Opioid Use Disorder: Effects of Opioid Maintenance Treatment and Detoxification

J Psychoactive Drugs. 2020 Jul-Aug;52(3):203-210. doi: 10.1080/02791072.2020.1751900. Epub 2020 Apr 17.

Abstract

The aim of the study was to explore whether abstinent patients on recent opioid detoxification or on opioid maintenance treatment suffer from sleeping problems. 199 patients on opioid maintenance treatment (methadone, diacetylmorphine and buprenorphine) or recent opioid detoxification were included in this exploratory cross-sectional study. We used the Pittsburgh Sleep Quality Index (PSQI) and the Regensburger Insomnia Scale (RIS) in order to assess potential sleeping problems. There was a significant effect of the condition "opioid maintenance" or "recent opioid detoxification" on the total score of PSQI and RIS. All opioid maintenance drugs used by the study population were associated with more sleeping problems compared to the detoxification group when calculated with RIS values. Recently abstinent patients (opioid detoxification) displayed significantly fewer sleep disturbances than opioid-maintained patients. Since sleeping problems can seriously impair treatment success and quality of life, screening for sleep disturbances and their subsequent treatment is of pronounced relevance.

Keywords: Opioid maintenance treatment; detoxification; opioid use disorder; sleep disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analgesics, Opioid / adverse effects
  • Buprenorphine / adverse effects
  • Cross-Sectional Studies
  • Female
  • Germany / epidemiology
  • Humans
  • Male
  • Methadone / adverse effects
  • Middle Aged
  • Opiate Substitution Treatment / adverse effects*
  • Opioid-Related Disorders / therapy*
  • Quality of Life
  • Sleep Wake Disorders / epidemiology*
  • Surveys and Questionnaires
  • Treatment Outcome
  • Young Adult

Substances

  • Analgesics, Opioid
  • Buprenorphine
  • Methadone