Abstract
We developed a host-guest ATP responsive strategy for efficient intracellular delivery of phosphopeptides, employing a pegylated arginine clustered calix[5]arene nanocarrier system that has great capability of recognizing the phosphate moieties on peptides and penetrating the cell membrane.
MeSH terms
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Adenosine Triphosphate / chemistry
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Adenosine Triphosphate / metabolism*
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Arginine / chemistry
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Arginine / metabolism
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Calixarenes / chemistry
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Calixarenes / metabolism
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Cell Membrane / chemistry
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Cell Membrane / metabolism
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Drug Carriers / chemistry
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Drug Carriers / metabolism
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HeLa Cells
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Humans
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Nanoparticles / chemistry
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Nanoparticles / metabolism
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Phosphopeptides / chemistry
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Phosphopeptides / metabolism*
Substances
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Drug Carriers
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Phosphopeptides
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Calixarenes
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Adenosine Triphosphate
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Arginine