A host-guest ATP responsive strategy for intracellular delivery of phosphopeptides

Chem Commun (Camb). 2020 May 21;56(41):5512-5515. doi: 10.1039/d0cc01800g.

Abstract

We developed a host-guest ATP responsive strategy for efficient intracellular delivery of phosphopeptides, employing a pegylated arginine clustered calix[5]arene nanocarrier system that has great capability of recognizing the phosphate moieties on peptides and penetrating the cell membrane.

MeSH terms

  • Adenosine Triphosphate / chemistry
  • Adenosine Triphosphate / metabolism*
  • Arginine / chemistry
  • Arginine / metabolism
  • Calixarenes / chemistry
  • Calixarenes / metabolism
  • Cell Membrane / chemistry
  • Cell Membrane / metabolism
  • Drug Carriers / chemistry
  • Drug Carriers / metabolism
  • HeLa Cells
  • Humans
  • Nanoparticles / chemistry
  • Nanoparticles / metabolism
  • Phosphopeptides / chemistry
  • Phosphopeptides / metabolism*

Substances

  • Drug Carriers
  • Phosphopeptides
  • Calixarenes
  • Adenosine Triphosphate
  • Arginine