Abstract
The biological roles of N6 methylation of nucleic acids have been extensively studied. Adenine methylation of RNA is the most prevalent RNA modification and has widespread effects on RNA splicing, translation, localization, and stability. Aberrant dynamic regulation of RNA N6-methyladenosine (m6A) has been reported in numerous human diseases, including several cancers. In recent years, eukaryotic DNA N6-methyladenosine (6mA) has also been reported and implicated in cancer progression and tumorigenesis. In this review, we summarize the contributions of N6-methyladenosine modification to cancer biology and pathogenesis in the context of both RNA and DNA. We also highlight the clinical relevance of targeting these modifications as a therapeutic strategy for cancer.
Keywords:
DNA methylation; N6-methyladenosine; RNA methylation; cancer; therapeutic targets.
Copyright: © 2020, Cancer Biology & Medicine.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Adenosine / analogs & derivatives
-
Adenosine / metabolism
-
Antineoplastic Agents / pharmacology
-
Antineoplastic Agents / therapeutic use
-
Carcinogenesis / drug effects
-
Carcinogenesis / genetics
-
DNA Methylation / drug effects
-
DNA Methylation / genetics*
-
Disease Progression
-
Epigenesis, Genetic / drug effects
-
Epigenesis, Genetic / genetics*
-
Gene Expression Regulation, Neoplastic / drug effects
-
Gene Expression Regulation, Neoplastic / genetics*
-
Humans
-
Methyltransferases / antagonists & inhibitors
-
Methyltransferases / metabolism
-
Neoplasms / diagnosis
-
Neoplasms / drug therapy
-
Neoplasms / genetics*
-
Neoplasms / pathology
-
Oxidoreductases, N-Demethylating / antagonists & inhibitors
-
Oxidoreductases, N-Demethylating / metabolism
-
RNA Processing, Post-Transcriptional / drug effects
-
RNA Processing, Post-Transcriptional / genetics*
-
RNA Splicing Factors
-
RNA-Binding Proteins / antagonists & inhibitors
-
RNA-Binding Proteins / metabolism
Substances
-
Antineoplastic Agents
-
RNA Splicing Factors
-
RNA-Binding Proteins
-
N-methyladenosine
-
Oxidoreductases, N-Demethylating
-
Methyltransferases
-
Adenosine