Evaluation of the 'ring sign' and the 'core sign' as a magnetic resonance imaging marker of disease activity and progression in clinically isolated syndrome and early multiple sclerosis

Nelly Blindenbacher; Eveline Brunner; Susanna Asseyer; Michael Scheel; Nadja Siebert; Ludwig Rasche; Judith Bellmann-Strobl; Alexander Brandt; Klemens Ruprecht; Dominik Meier; Jens Wuerfel; Friedemann Paul; Tim Sinnecker

doi:10.1177/2055217320915480

Evaluation of the 'ring sign' and the 'core sign' as a magnetic resonance imaging marker of disease activity and progression in clinically isolated syndrome and early multiple sclerosis

Mult Scler J Exp Transl Clin. 2020 Mar 30;6(1):2055217320915480. doi: 10.1177/2055217320915480. eCollection 2020 Jan-Mar.

Authors

Nelly Blindenbacher¹, Eveline Brunner¹, Susanna Asseyer², Michael Scheel², Nadja Siebert², Ludwig Rasche², Judith Bellmann-Strobl², Alexander Brandt², Klemens Ruprecht³, Dominik Meier¹, Jens Wuerfel¹, Friedemann Paul^{2

4

3}, Tim Sinnecker^{1

2

5

6}

Affiliations

¹ qbig, Department of Biomedical Engineering, University of Basel, Switzerland.
² Neurocure Clinical Research Center, Charité-Universitätsmedizin Berlin, Germany.
³ Department of Neurology, Charité-Universitätsmedizin Berlin, Germany.
⁴ Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, and Berlin Institute of Health and Max Delbrück Center for Molecular Medicine, Germany.
⁵ Medical Image Analysis Center AG, Switzerland.
⁶ Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland.

Abstract

Background: Brain lesions with a hypointense ring or core were described in multiple sclerosis on susceptibility weighted imaging.

Objective: The purpose of this study was to study the evolution and prognostic relevance of susceptibility weighted imaging hypointense lesions in clinically isolated syndrome and early multiple sclerosis.

Methods: Sixty-six early multiple sclerosis and clinically isolated syndrome patients were followed over a median period of 2.9 years (range 1.6-4.6 years) and underwent 3T magnetic resonance imaging including 3D susceptibility weighted imaging and T2-weighted fluid-attenuated inversion recovery. We assessed the presence of susceptibility weighted imaging hypointense core or ring lesions, and Expanded Disability Status Scale at baseline and follow-up.

Results: Of 611 lesions at baseline, 64 (10.5%) had a susceptibility weighted imaging hypointense core, and 28 (4.6%) had a susceptibility weighted imaging hypointense ring. Hypointense ring lesions were larger (p < 0.001) and more T1w hypointense (p = 0.002) than others. During follow-up, hypointense core lesions became susceptibility weighted imaging isointense (52 lesions, 81%); few developed into hypointense ring lesions (two lesions, 3%). Hypointense ring lesions did not shrink on T2-weighted fluid-attenuated inversion recovery images (p = 0.077, trend towards more enlargement compared to others), while hypointense core lesions more often shrunk in comparison to lesions without a hypointense core (p = 0.002). The number of susceptibility weighted imaging hypointense ring lesions at baseline correlated with Expanded Disability Status Scale progression at follow-up (p = 0.021, R = 0.289).

Conclusion: In our cohort of patients with clinically isolated syndrome or early multiple sclerosis, susceptibility weighted imaging hypointense ring lesions were only rarely detectable, but did not shrink and were associated with future disability progression.

Keywords: 3 Tesla MRI; Multiple sclerosis; clinically isolated syndrome; ring sign; susceptibility weighted imaging.