Evidence for eosinophil and IL-17 mediated inflammation in allergic rhinitis

Kawa Amin; Sulaf Mosa Issa; Kosar Mohammad Ali; Muaid Ismiel Aziz; Huner Mohamed Hama Amieen; Jonas Bystrom; Christer Janson

doi:10.1186/s12948-020-00117-6

Evidence for eosinophil and IL-17 mediated inflammation in allergic rhinitis

Clin Mol Allergy. 2020 Apr 4:18:6. doi: 10.1186/s12948-020-00117-6. eCollection 2020.

Authors

Kawa Amin^{1

2}, Sulaf Mosa Issa¹, Kosar Mohammad Ali¹, Muaid Ismiel Aziz¹, Huner Mohamed Hama Amieen³, Jonas Bystrom⁴, Christer Janson²

Affiliations

¹ 1Department of Medicine and Microbiology/Immunology, College of Medicine, University of Sulaimani, Sulaimanyah, Iraq.
² 2Department of Medical Science, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
³ Otolaryngology Center, Sulaimani Teaching Hospital, Sulaimanyah, Iraq.
⁴ 4Expermiental Medicine and Rheumatology, William Harvey Research Institute, Barts & The London, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ UK.

Abstract

Background: The aim was to determine the level of inflammatory cytokines, eosinophil cationic protein and IgE in allergic rhinitis (AR) patients.

Subjects and methods: Blood samples were taken from 88 AR patients and 88 healthy controls (HC). Each sample was analysed for eosinophil counts by flow cytometry, IgE by ECLIA, ECP, IL-17, and IL-33 by using ELISA test.

Results: There was no significant difference between AR patients and the control group in age and gender. Levels of eosinophils, IgE, ECP, IL-17, IL-33 and the total symptom scores were significantly higher in AR patients than the HC (P = 0.0001). Serum ECP correlated with IL-17 (P = 0.041, r = 0.42), IL-33 (P = 0.0001, r = 080), and IgE levels (P = 0.017, r = 0.45) in the R patients. There was no correlation between IL-17 and IL-33. There was a correlation between symptom scores and eosinophils (P = 0.026, r = 0.52), and IgE (P = 0.001, r = 0.60) in the patients. No correlation was observed between symptom scores and ECP, IL-17, and IL-33 in the AR patient.

Conclusions: Patients with AR have significant higher serum levels of ECP, IL-17, and IL-33 than healthy controls. This indicates that these markers could be used to in order to diagnose AR and to monitor disease. Inhibitory molecules to IL-17 and IL-33 may be considered as novel treatment strategies.

Keywords: Allergic rhinitis; ECP; IL-17; IL-33; IgE; Immune system.