The Role of Allergic Rhinitis in Chronic Rhinosinusitis

Immunol Allergy Clin North Am. 2020 May;40(2):201-214. doi: 10.1016/j.iac.2019.12.010. Epub 2020 Jan 14.

Abstract

This literature review collates and summarizes recent literature to explore the relationship between chronic rhinosinusitis (CRS) and allergy. The relationship between CRS and allergy is not fully understood. However, current evidence suggests a relationship between allergy and specific endotypes of CRS with nasal polyposis, including allergic fungal rhinosinusitis and central compartment atopic disease. Specific endotypes of CRS with nasal polyps seem to have an association with allergy. More evidence is necessary to better characterize this relationship. Level of evidence: 5.

Keywords: Allergic rhinitis; Allergy; Atopy; Chronic rhinosinusitis; Nasal polyposis; Sinusitis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chronic Disease
  • Cytokines / metabolism
  • Humans
  • Hypersensitivity, Immediate
  • Nasal Polyps / complications
  • Nasal Polyps / immunology*
  • Rhinitis / complications
  • Rhinitis / immunology*
  • Rhinitis, Allergic / complications
  • Rhinitis, Allergic / immunology*
  • Sinusitis / complications
  • Sinusitis / immunology*
  • Th2 Cells / immunology*

Substances

  • Cytokines