Placental microRNA dataset of monochorionic twin pregnancies with and without selective fetal growth restriction

Meng Meng; Yvonne Kwun Yue Cheng; Linda Ling Wu; Piya Chaemsaithong; Maran Bo Wah Leung; Stephen Siu Chung Chim; Daljit Singh Sahota; Wei Li; Liona Chiu Yee Poon; Chi Chiu Wang; Tak Yeung Leung

doi:10.1016/j.dib.2020.105403

Placental microRNA dataset of monochorionic twin pregnancies with and without selective fetal growth restriction

Data Brief. 2020 Mar 9:30:105403. doi: 10.1016/j.dib.2020.105403. eCollection 2020 Jun.

Affiliation

¹ Department of Obstetrics and Gynaecology, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong.

Abstract

To compare the whole genomic microRNA (miRNA) between the selective fetal growth restriction (sFGR) twin and the normally growing (control) co-twin in monochorionic (MC) twin pregnancies. MC twin pregnancies with or without sFGR were recruited, and their placental miRNAs were profiled by microarray. The ratio of the placental miRNA of the sFGR twin to that of the normally larger co-twin were calculated and compared to that of the control twin pairs. The miRNA microarray intensity amongst normal and sFGR large and small twins are shown. The expression data presented here will facilitate other researchers who are working on placental regulation and mechanism in pregnancy complicated by fetal growth restriction. The dataset supports the research article entitle "Whole genome miRNA profiling revealed miR-199a as potential placental pathogenesis of selective fetal growth restriction in monochorionic twin pregnancies" [1].

Keywords: Fetal growth restriction; MicroRNA; Microarray; Mitochondria; Placenta; Pregnancy; Selective fetal growth restriction; Twin pregnancy.