Cytotoxic aspidosperma-type alkaloids from Melodinus suaveolens

Fitoterapia. 2020 Jun:143:104588. doi: 10.1016/j.fitote.2020.104588. Epub 2020 Apr 6.

Abstract

Four new aspidosperma-type alkaloids, melosuavines J-M (1-4) were isolated from the leaves of Melodinus suaveolens. Their structures with absolute configurations were elucidated by extensive HRESIMS and NMR spectroscopic analysis, as well as ECD calculations and Mosher's method. Their cytotoxic activities against four human cancer cell lines were also evaluated.

Keywords: Alkaloids; Aspidosperma-type; Cytotoxic activities; Melodinus suaveolens.

MeSH terms

  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Apocynaceae / chemistry*
  • Cell Line, Tumor
  • China
  • Humans
  • Molecular Structure
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Leaves / chemistry*

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Phytochemicals