Exercise and Nutritional Approaches to Combat Cancer-Related Bone and Muscle Loss

Curr Osteoporos Rep. 2020 Jun;18(3):291-300. doi: 10.1007/s11914-020-00589-0.

Abstract

Purpose of review: The aim of this narrative review is to summarise recent literature on the effects of exercise and nutrition interventions alone or in combination on muscle and bone loss in people with cancer.

Recent findings: There is emerging evidence to support the inclusion of targeted exercise and nutrition strategies to counter loss of muscle and bone associated with cancer treatments. Although research in this field is advancing, the optimal exercise and nutrition prescription to combat cancer-related bone and muscle loss remain unknown. This review identifies specific components of nutrition and exercise interventions that are promising although require further exploration through studies designed to determine the effect on muscle and bone. A focused research effort is required to elucidate the full potential of exercise and nutrition intervention for people with cancer at risk of bone and muscle loss.

Keywords: Bone; Cancer; Diet; Exercise; Muscle; Nutrition; Sarcopenia.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents, Hormonal / adverse effects
  • Bone Density Conservation Agents / therapeutic use
  • Bone Diseases, Metabolic / etiology
  • Bone Diseases, Metabolic / prevention & control*
  • Bone Diseases, Metabolic / therapy
  • Calcium / therapeutic use
  • Dairy Products
  • Diet Therapy*
  • Dietary Proteins
  • Dietary Supplements
  • Exercise
  • Exercise Therapy*
  • Fatty Acids, Omega-3 / therapeutic use
  • Humans
  • Neoplasms / complications
  • Neoplasms / therapy*
  • Radiotherapy / adverse effects
  • Sarcopenia / etiology
  • Sarcopenia / prevention & control*
  • Sarcopenia / therapy
  • Vitamin D / therapeutic use

Substances

  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal
  • Bone Density Conservation Agents
  • Dietary Proteins
  • Fatty Acids, Omega-3
  • Vitamin D
  • Calcium