Emerging Roles for Noncoding RNAs in Autoimmune Thyroid Disease

Endocrinology. 2020 Aug 1;161(8):bqaa053. doi: 10.1210/endocr/bqaa053.

Abstract

Autoimmune thyroid disease (AITD) is one of the most frequent autoimmune disorders. However, the pathogenesis of AITD has not been fully elucidated. Recently, accumulating evidence has demonstrated that abnormal expression of noncoding RNAs (ncRNAs) is closely related to the etiopathogenesis of AITD. microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) are 3 major groups of ncRNAs that are attracting increasing attention. Herein, we summarized our present knowledge on the role of miRNAs, lncRNAs, and circRNAs in AITD. This review focused on the importance of ncRNAs in development of the most prevalent AITD, such as Hashimoto disease and Graves' diseases. Altogether, the main purpose of this review is to provide new insights in the pathogenesis of AITD and the possibility of developing novel potential therapeutic targets.

Keywords: AITD; circRNA; lncRNA; miRNA; ncRNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology
  • Autoimmune Diseases / therapy
  • Hashimoto Disease / genetics
  • Hashimoto Disease / immunology
  • Hashimoto Disease / pathology
  • Hashimoto Disease / therapy
  • Humans
  • Molecular Targeted Therapy / methods
  • Molecular Targeted Therapy / trends
  • RNA, Long Noncoding / physiology
  • RNA, Untranslated / physiology*
  • Thyroiditis, Autoimmune / genetics*
  • Thyroiditis, Autoimmune / immunology
  • Thyroiditis, Autoimmune / pathology
  • Thyroiditis, Autoimmune / therapy

Substances

  • RNA, Long Noncoding
  • RNA, Untranslated