Astrocytogenesis: where, when, and how

Ekin Su Akdemir; Anna Yu-Szu Huang; Benjamin Deneen

doi:10.12688/f1000research.22405.1

Astrocytogenesis: where, when, and how

F1000Res. 2020 Apr 2:9:F1000 Faculty Rev-233. doi: 10.12688/f1000research.22405.1. eCollection 2020.

Authors

Ekin Su Akdemir^#^{1

2}, Anna Yu-Szu Huang^#^{1

2}, Benjamin Deneen^{1

2

3

4}

Affiliations

¹ Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, 77030, USA.
² Program in Developmental Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
³ Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA.
⁴ Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA.

^# Contributed equally.

Abstract

Astrocytes are the most abundant cell type in the central nervous system and have diverse functions in blood-brain barrier maintenance, neural circuitry formation and function, and metabolic regulation. To better understand the diverse roles of astrocytes, we will summarize what is known about astrocyte development and the challenges limiting our understanding of this process. We will also discuss new approaches and technologies advancing the field.

Keywords: Astrocyte; Glia; Gliogenesis; Neurodevelopment.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Astrocytes / cytology*
Blood-Brain Barrier
Central Nervous System
Humans
Neurogenesis*

Grants and funding

This work was supported by the National Institutes of Health (NINDS NS071153, NIMH AG054111) and the National Multiple Sclerosis Society (RG-1501-02756). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.