pH-responsive hierarchical transformation of charged lipid assemblies within polyelectrolyte gel layers with applications for controlled drug release and MR imaging contrast

Yi-Fong Huang; Wen-Hsuan Chiang; Wen-Chia Huang; Hsin-Hung Chen; Ming-Yin Shen; Sung-Chyr Lin; Chorng-Shyan Chern; Hsin-Cheng Chiu

doi:10.1039/c4tb00771a

pH-responsive hierarchical transformation of charged lipid assemblies within polyelectrolyte gel layers with applications for controlled drug release and MR imaging contrast

J Mater Chem B. 2014 Aug 21;2(31):4988-4992. doi: 10.1039/c4tb00771a. Epub 2014 Jul 3.

Authors

Yi-Fong Huang¹, Wen-Hsuan Chiang, Wen-Chia Huang, Hsin-Hung Chen, Ming-Yin Shen, Sung-Chyr Lin, Chorng-Shyan Chern, Hsin-Cheng Chiu

Affiliation

¹ Department of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan.

PMID: 32261831
DOI: 10.1039/c4tb00771a

Abstract

A cationic lipid-embedded poly(acrylic acid) (PAAc) gel layer coated on chitosan/superparamagnetic iron oxide nanoparticle (SPION) nanohybrid surfaces effectively modulates drug release and MR imaging contrast by pH-responsive morphological transformation and hierarchical alignment of the lipid assemblies.