Carboxylic silane-exchanged manganese ferrite nanoclusters with high relaxivity for magnetic resonance imaging

Yingzhe Qi; Chen Shao; Wei Gu; Fuying Li; Yunlong Deng; Hansheng Li; Ling Ye

doi:10.1039/c3tb00037k

Carboxylic silane-exchanged manganese ferrite nanoclusters with high relaxivity for magnetic resonance imaging

J Mater Chem B. 2013 Apr 7;1(13):1846-1851. doi: 10.1039/c3tb00037k. Epub 2013 Feb 20.

Authors

Yingzhe Qi¹, Chen Shao, Wei Gu, Fuying Li, Yunlong Deng, Hansheng Li, Ling Ye

Affiliation

¹ School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, P. R. China. lingye@ccmu.edu.cn.

PMID: 32261150
DOI: 10.1039/c3tb00037k

Abstract

To improve the magnetic properties and MRI contrast effect of Fe₃O₄ superparamagnetic nanoparticles (NPs), a series of oleate-capped, Mn-doped Mn_xFe_(1-x)Fe₂O₄ (x≤ 0.4) NPs was prepared via a thermal decomposition method and subsequently assembled into nanoclusters by the carboxylic silane. The effects of Mn doping and clustering on the magnetization, relaxivity and contrast enhancement of the Mn_xFe_(1-x)Fe₂O₄ (x≤ 0.4) NPs were studied. Our results revealed that the Mn_xFe_(1-x)Fe₂O₄ NPs exhibited the highest saturation magnetization of 82.55 emu g^-1 when x = 0.05. Correspondingly, the assembled Mn_0.05Fe_(1-0.05)Fe₂O₄ nanoclusters showed the highest relaxivity value of 528 (Mn + Fe) mM^-1 s^-1 and an enhanced MRI contrast in mouse liver. In addition, the MTT and H&E analysis confirmed that Mn_0.05Fe_(1-0.05)Fe₂O₄ nanoclusters were non-toxic. Therefore, the biocompatible Mn_0.05Fe_(1-0.05)Fe₂O₄ nanoclusters with superior relaxometric properties hold great potential in serving as a novel MRI nanoprobe.