Advances on Chelation and Chelator Metal Complexes in Medicine

Int J Mol Sci. 2020 Apr 3;21(7):2499. doi: 10.3390/ijms21072499.

Abstract

Metal ions such as iron, copper and zinc are essential for life. Chelators (Chele, greek χειλή-claw of a crab) are organic molecules possessing specific ligands which have high affinity and can bind/carry metal ions and play very important roles in living systems e.g., haemoglobin, transferrin, phytochelators and microbial siderophores [...].

Keywords: antioxidants; chelating drugs; chelators; deferiprone; diagnostics; metal complexes; theranostics; therapeutics.

Publication types

  • Editorial

MeSH terms

  • Chelating Agents / chemistry*
  • Chelating Agents / therapeutic use
  • Chelation Therapy
  • Coordination Complexes / chemistry*
  • Coordination Complexes / therapeutic use
  • Copper / chemistry
  • Humans
  • Iron / chemistry
  • Ligands
  • Zinc / chemistry

Substances

  • Chelating Agents
  • Coordination Complexes
  • Ligands
  • Copper
  • Iron
  • Zinc