1 Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, Rua Dr. Plácido da Costa, s/n, 4200-450 Porto, Portugal.
2 Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, s/n, 4200-450 Porto, Portugal.
3 Department of Human Genetics, Faculty of Medicine, University of Porto/Centro Hospitalar São João, Porto, Portugal.
4 Institute for Research and Innovation in Health/Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.