Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles

Peng-Hao Hsu; Carina Arboleda; Alexandra Stubelius; Ling-Wei Li; Jason Olejniczak; Adah Almutairi

doi:10.1039/c9bm02019e

Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles

Biomater Sci. 2020 May 6;8(9):2394-2397. doi: 10.1039/c9bm02019e.

Authors

Peng-Hao Hsu¹, Carina Arboleda², Alexandra Stubelius³, Ling-Wei Li³, Jason Olejniczak¹, Adah Almutairi⁴

Affiliations

¹ Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. aalmutairi@ucsd.edu.
² Department of NanoEngineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
³ Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
⁴ Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. aalmutairi@ucsd.edu and Department of NanoEngineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.

PMID: 32255451
DOI: 10.1039/c9bm02019e

Abstract

We synthesized an oxidation-responsive polycaprolactone (O-PCL) bearing pendant arylboronic esters as H2O2-responsive motifs. H2O2 induces fast depolymerization of O-PCL within days. Nanoparticles formulated from O-PCL disintegrate and release payload in response to concentrations of H2O2 (50 μM) that are relevant to human disease.

MeSH terms

Cell Survival / drug effects
Fibroblasts / drug effects
Hydrogen Peroxide / chemistry*
Macrophages / drug effects
Nanoparticles / administration & dosage
Nanoparticles / chemistry*
Oxidation-Reduction
Polyesters / administration & dosage
Polyesters / chemistry*

Substances

Polyesters
polycaprolactone
Hydrogen Peroxide