Sinusoidal obstruction syndrome

Victor de Lédinghen; Alban Villate; Marie Robin; Marie Decraecker; Dominique Valla; Sophie Hillaire; Virginia Hernandez-Gea; Danielle Dutheil; Christophe Bureau; Aurélie Plessier

doi:10.1016/j.clinre.2020.03.019

Sinusoidal obstruction syndrome

Clin Res Hepatol Gastroenterol. 2020 Sep;44(4):480-485. doi: 10.1016/j.clinre.2020.03.019. Epub 2020 Apr 3.

Authors

Affiliations

¹ Department of Hepatology and INSERM U1053, Haut-Lévêque Hospital, University Hospital of Bordeaux, avenue Magellan, 33600 Pessac, France. Electronic address: victor.deledinghen@chu-bordeaux.fr.
² Department of Hematology, Bretonneau Hospital, University hospital of Tours, 2, boulevard Tonnellé, 37000 Tours, France.
³ Department of Hematology, Saint-Louis Hospital, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France.
⁴ Department of Hepatology and INSERM U1053, Haut-Lévêque Hospital, University Hospital of Bordeaux, avenue Magellan, 33600 Pessac, France.
⁵ Department of Hepatology, DHU Unity, Beaujon Hospital, AP-HP, 100, boulevard du Général-Leclerc, 92118 Clichy, France; French Network for Rare Liver Diseases FILFOIE, Saint-Antoine Hospital, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
⁶ Department of Internal Medicine, Foch Hospital, 40, rue Worth, 92150 Suresnes, France.
⁷ Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic, Institut de Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona. Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERehd). Health Care Provider of the European Reference Network onRare Liver Disorders (ERN-Liver), Spain.
⁸ Liver Vascular Disease Patient Organisation (AMVF), Beaujon Hospital, Department of Hepatology, 100, boulevard du Général-Leclerc, 92118 Clichy, France.
⁹ Department of Gastroenterology and Hepatology, Rangueil Hospital, University Hospital of Toulouse, 1, avenue du Professeur-Jean-Poulhès, 31400 Toulouse, France.
¹⁰ Department of Hepatology, DHU Unity, Beaujon Hospital, AP-HP, 100, boulevard du Général-Leclerc, 92118 Clichy, France; French Network for Rare Liver Diseases FILFOIE, Saint-Antoine Hospital, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France; Reference center of vascular liver diseases, European Reference Network (ERN) 'Rare-Liver', France.

PMID: 32253162
DOI: 10.1016/j.clinre.2020.03.019

Abstract

Sinusoidal obstruction syndrome (SOS), previously known as veno-occlusive disease, is characterized by concentric and non-thrombotic obstruction of the sinusoid and central vein lumen with no identified primitive or thrombotic hepatic vein lesions. The initial lesion is a result of endothelial denudation, corresponding to the migration of damaged sinusoidal cells to the central veins of the hepatic lobules, leading to sinusoidal and veno-occlusive congestive obstruction. SOS may be associated with other lesions such as centrilobular perisinusoidal fibrosis, peliosis, or nodular regenerative hyperplasia. The first cases of SOS were documented in 1920 in South Africa, after ingestion of food sources contaminated by pyrrolizidine alkaloids. SOS is a well-known complication of hematopoietic stem cell transplantation (HSCT). Numerous toxins and drugs have been associated with SOS, mainly chemotherapies and immunosuppressive therapies, as well as total body or liver irradiation and ABO mismatch platelet transfusion. The pathogenesis of this entity remains unknown.

Keywords: Hematopoietic stem cells transplant; Hepatic Veno-occlusive disease; Sinusoidal obstruction syndrome.

MeSH terms

Hepatic Veno-Occlusive Disease / diagnosis*
Hepatic Veno-Occlusive Disease / therapy*
Humans
Practice Guidelines as Topic