The first imported case of extensively drug-resistant Salmonella enterica serotype Typhi infection in Taiwan and the antimicrobial therapy

J Microbiol Immunol Infect. 2021 Aug;54(4):740-744. doi: 10.1016/j.jmii.2020.03.017. Epub 2020 Mar 25.

Abstract

The first imported case of XDR typhoid fever in Taiwan contracted with a bacterial strain, which was most closely related to the blaCTX-M-15-carrying strains linked to Pakistan. Meropenem, in combination with an antimicrobial with intracellular activity against Salmonella, should be used for the treatment of XDR typhoid fever.

Keywords: Ceftriaxone; Drug resistance; Fluoroquinolones; Salmonella enterica serovar Typhi; Travel medicine; Typhoid fever.

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Communicable Diseases, Imported / microbiology*
  • Drug Resistance, Multiple, Bacterial*
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Pakistan
  • Salmonella typhi / classification
  • Salmonella typhi / drug effects*
  • Salmonella typhi / genetics
  • Salmonella typhi / pathogenicity*
  • Serogroup
  • Taiwan
  • Travel-Related Illness
  • Typhoid Fever / diagnosis
  • Typhoid Fever / drug therapy*
  • Typhoid Fever / microbiology*
  • Young Adult

Substances

  • Anti-Bacterial Agents