Abstract
A course of treatment with humic acids extracted with sodium pyrophosphate from high-moor pine-peat moss-cotton grass peat improves humoral immune response of C57BL/6 mice, stimulates the production of TNFα, IL-1β, and IL-12 by the animal peritoneal macrophages and the production of IFNγ and TNFα by donor peripheral blood mononuclears, causing no changes in the production of IL-10 in vitro.
Keywords:
cytokines; humic acids; humoral immune response.
MeSH terms
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Animals
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Cells, Cultured
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Cytokines / metabolism*
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Humans
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Humic Substances* / analysis
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Immunity, Humoral / drug effects*
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Immunity, Humoral / physiology
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Immunocompetence / drug effects
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Leukocytes, Mononuclear / drug effects
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Leukocytes, Mononuclear / metabolism
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Macrophages, Peritoneal / drug effects
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Macrophages, Peritoneal / metabolism
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Male
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Mice
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Mice, Inbred C57BL
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Pinus / chemistry
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Poaceae / chemistry
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Sphagnopsida / chemistry
Substances
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Cytokines
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Humic Substances