Effects of Humic Acids, Isolated from High-Moor Pine-Peat Moss-Cotton Grass Peat on the Production of Cytokines by Mouse and Human Immunocompetent Cells and on Humoral Immune Response

Bull Exp Biol Med. 2020 Mar;168(5):651-653. doi: 10.1007/s10517-020-04772-2. Epub 2020 Apr 4.

Abstract

A course of treatment with humic acids extracted with sodium pyrophosphate from high-moor pine-peat moss-cotton grass peat improves humoral immune response of C57BL/6 mice, stimulates the production of TNFα, IL-1β, and IL-12 by the animal peritoneal macrophages and the production of IFNγ and TNFα by donor peripheral blood mononuclears, causing no changes in the production of IL-10 in vitro.

Keywords: cytokines; humic acids; humoral immune response.

MeSH terms

  • Animals
  • Cells, Cultured
  • Cytokines / metabolism*
  • Humans
  • Humic Substances* / analysis
  • Immunity, Humoral / drug effects*
  • Immunity, Humoral / physiology
  • Immunocompetence / drug effects
  • Leukocytes, Mononuclear / drug effects
  • Leukocytes, Mononuclear / metabolism
  • Macrophages, Peritoneal / drug effects
  • Macrophages, Peritoneal / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Pinus / chemistry
  • Poaceae / chemistry
  • Sphagnopsida / chemistry

Substances

  • Cytokines
  • Humic Substances