Quantum Dots for Assessment of Reactive Oxygen Species Accumulation During Chemotherapy and Radiotherapy

Kimal Honour Djam; Bong Han Lee; Sindhuja Suresh; Andrew Edet Ekpenyong

doi:10.1007/978-1-0716-0463-2_19

Quantum Dots for Assessment of Reactive Oxygen Species Accumulation During Chemotherapy and Radiotherapy

Methods Mol Biol. 2020:2135:293-303. doi: 10.1007/978-1-0716-0463-2_19.

Authors

Kimal Honour Djam¹, Bong Han Lee¹, Sindhuja Suresh¹, Andrew Edet Ekpenyong²

Affiliations

¹ Department of Physics, Creighton University, Omaha, NE, USA.
² Department of Physics, Creighton University, Omaha, NE, USA. andrewekpenyong@creighton.edu.

PMID: 32246344
DOI: 10.1007/978-1-0716-0463-2_19

Abstract

Quantum dots (QDs) are semiconductor nanoparticles ranging in size from 2 to 10 nm. QDs are increasingly being developed for biomedical imaging, targeted drug delivery, and green energy technology. Here we describe the novel utilization of biocompatible CdSe-ZnS core-shell semiconductor nanoparticles for assessment of reactive oxygen species (ROS) in the context of chemotherapy and radiotherapy, both of which are important modalities in the treatment of cancer.

Keywords: Cancer; Chemotherapy; Daunorubicin; Doxorubicin; Fluorescence; Quantum dot; Radiotherapy; Reactive oxygen species.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cadmium Compounds / chemistry
Cell Line, Tumor
Drug Delivery Systems
Drug Therapy / methods
Drug-Related Side Effects and Adverse Reactions / metabolism*
Humans
Quantum Dots / chemistry*
Radiotherapy / adverse effects
Reactive Oxygen Species / analysis*
Reactive Oxygen Species / chemistry
Selenium Compounds / chemistry
Sulfides / chemistry
Zinc Compounds / chemistry

Substances

Cadmium Compounds
Reactive Oxygen Species
Selenium Compounds
Sulfides
Zinc Compounds